Hormonal Regulation of the Menstrual Cycle

Selected Recent Publications

Angelean O. Hendrix and James F. Selgrade (2014). Bifurcation analysis of a menstrual cycle model reveals multiple mechanisms linking testosterone and classical PCOS. J. Theoretical Biology 361, 31-40.   Research supported by NSF grants DMS-0920927 and DMS-1225607

Angelean O. Hendrix, Claude L. Hughes and James F. Selgrade (preprint). (2014) Modeling endocrine control of the pituitary-ovarian axis: Androgenic influence and chaotic dynamics. Bull. Math. Biology 76, 136-156.   Research supported by NSF grants DMS-0920927 and DMS-1225607

Alison Margolskee and J.F. Selgrade. (2013). A lifelong model for the female reproductive cycle with an antimullerian hormone treatment to delay menopause, J. Theoretical Biology 326, 21-35.   http://dx.doi.org/10.1016/j.jtbi.2013.02.007   Research supported by NSF grants DMS-0920927 and DMS-1225607

Alison Margolskee and J.F. Selgrade. (2011). Dynamics and bifurcation of a model for hormonal control of the menstrual cycle with inhibin delay, Math. Biosciences 234, 95-107.   http://dx.doi.org/10.1016/j.mbs.2011.09.001   Research supported by NSF grant DMS-0920927

James F. Selgrade (2010). Bifurcation analysis of a model for hormonal regulation of the menstrual cycle, Math. Biosciences 225, 97-103.   http://dx.doi.org/10.1016/j.mbs.2010.02.004   Research supported by NSF grant DMS-0920927

Leona A. Harris and James F. Selgrade (2013). Modeling endocrine regulation of the menstrual cycle using delay differential equations, preprint


Animations of Bifurcations

Decreasing the diameter of the cycle uniqueness interval as c_2 increases

An unfolding of a transcritical bifurcation as tau increases

A family of transcritical bifurcations as c_2 and tau vary


Matlab Code for Solving Delay Differential Equations

ddeRK4 code